Research Published

Spreading the Bright Lights of Discovery

As LRI discoveries are published in top journals, the hundreds of thousands of scientists and clinicians who read them step that much closer to better treating and actually curing lupus.

The Journal of Immunology
The New England Journal of Medicine
Annals of Internal Medicine

Select publications from LRI Midwest Researchers…


Anti-DNA B cells in MRL/lpr mice show altered differentiation and editing pattern. Li Y, Li H, Ni D, Weigert M. J Exp Med. 2002 Dec 16;196(12):1543-52.

Secondary heavy chain rearrangement: a mechanism for generating anti-double-stranded DNA B cells. Sekiguchi DR, Eisenberg RA, Weigert M. J Exp Med. 2003 197(1):27-39.

Development and Selection of Edited B Cells in B6.56R Mice. Sekiguchi DR, Yunk L, Gary D, Charan D, Srivastava B, Allman D, Weigert MG, Prak ET. J Immunol. 2006 176(11):6879-87.

Light chain editing generates polyreactive antibodies in chronic graft-versus-host reaction. Witsch EJ, Cao H, Fukuyama H, Weigert M. J Exp Med 2006 Jul 10;203(7):1761-72. Epub 2006 Jun 26

Dnase1l3 deficiency in lupus-prone MRL and NZB/W F1 mice. Clin Exp Immunol. 2003 Oct;134(1):46-52. Wilber A, O'Connor TP, Lu ML, Karimi A, Schneider MC.


Accelerated macrophage apoptosis induces autoantibody formation and organ damage in systemic lupus erythematosus.Denny MF, Chandaroy P, Killen PD, Caricchio R, Lewis EE, Richardson BC, Lee KD, Gavalchin J, Kaplan MJ. J Immunol. 2006 Feb 15;176(4):2095-104.

Plasminogen activator inhibitor-1 is associated with impaired endothelial function in women with systemic lupus erythematosus. Somers EC, Marder W, Kaplan MJ, Brook RD, McCune WJ. Ann N Y. Acad Sci. 2005 1051:271-80.

Apoptosis in systemic lupus erythematosus.Kaplan MJ. Clin Immunol. 2004 Sep; 112(3):210-8.

Endothelial cell apoptosis in systemic lupus erythematosus: a common pathway for abnormal vascular function and thrombosis propensity. Rajagopalan S, Somers EC, Brook RD, Kehrer C, Pfenninger D, Lewis E, Chakrabarti A, Richardson BC, Shelden E, McCune WJ, Kaplan MJ. Blood. 2004 103(10):3677-83.


Elevated Serum Levels of Interferon-Regulated Chemokines Are Biomarkers for Active Human Systemic Lupus Erythematosus. Bauer JW, Baechler EC, Petri M, Batliwalla FM, Crawford D, Ortmann WA, Espe KJ, Li W, Patel DD, Gregersen PK, Behrens TW. PLoS Med. 2006 Dec 19;3(12):e491.


Role of endonuclease G in neuronal excitotoxicity in mice. Wu Y, Dong M, Toepfer NJ, Fan Y, Xu M, Zhang J. Neurosci Lett. 2004 Jul 8;364(3):203-7.

Endonuclease G is required for early embryogenesis and normal apoptosis in mice. Zhang J, Dong M, Li L, Fan Y, Pathre P, Dong J, Lou D, Wells JM, Olivares-Villagomez D, Van Kaer L, Wang X, Xu M. Proc Natl Acad Sci U S A. 2003 Dec 23;100(26):15782-7. Epub 2003 Dec 8.


c-Jun NH2-terminal kinase 2 inhibits gamma interferon production during Anaplasma phagocytophilum infection. Pedra JH, Mattner J, Tao J, Kerfoot SM, Davis RJ, Flavell RA, Askenase PW, Yin Z, Fikrig E. Infect Immun. 2008 Jan;76(1):308-16. Epub 2007 Nov 12.

Liver autoimmunity triggered by microbial activation of natural killer T cells. Mattner J, Savage PB, Leung P, Oertelt SS, Wang V, Trivedi O, Scanlon ST, Pendem K, Teyton L, Hart J, Ridgway WM, Wicker LS, Gershwin ME, Bendelac A. Cell Host Microbe. 2008 May 15;3(5):304-15.

Regulatory roles for NKT cell ligands in environmentally induced autoimmunity. Vas J, Mattner J, Richardson S, Ndonye R, Gaughan JP, Howell A, Monestier M. Nat Chem Biol. 2007 Sep;3(9):559-64. Epub 2007 Jul 29.

Synthesis and evaluation of stimulatory properties of Sphingomonadaceae glycolipids. Long X, Deng S, Mattner J, Zang Z, Zhou D, McNary N, Goff RD, Teyton L, Bendelac A, Savage PB. J Immunol. 2008 Nov 15;181(10):6779-88.

Regulatory roles for NKT cell ligands in environmentally induced autoimmunity. Vas J, Mattner J, Richardson S, Ndonye R, Gaughan JP, Howell A, Monestier M. J Immunol. 2008 Nov 15;181(10):6779-88.

See more on research published from other areas of the country here

“The quality and quantity of these studies, and the high number of times that other scientists cite them, shows what a dramatic impact the Institute is having on finding solutions to lupus.”

– Nicholas Chiorazzi, M.D., Director of the Laboratory of Experimental Immunology, Feinstein Institute for Medical Research