Major Breakthroughs

Results Are What Matter

In funding ideas that others wouldn’t risk—85 new ideas—the LRI has energized and advanced immune system research in lupus.

“The speed with which the Institute has changed the outlook for lupus research is remarkable.” – William E. Paul, MD, Chief, Laboratory of Immunology, NIAID-NIH, NIH Distinguished Investigator and chairman of the Lupus Research Institute’s scientific advisory board.

Key Lupus Research Institute Discoveries

  • Genes that Increase Susceptibility to Lupus

    We’ve identified two genes that make lupus-prone mice susceptible to lupus—fresh insight into how the disease develops. Scientists are now examining if the same genes are defective in people with lupus.

  • How Lupus Damages Organs—Kidneys, Heart, Brain, Skin

    We’ve confirmed five novel explanations for how lupus damages vital organs such as the kidneys, brain, and heart. Now there is real hope for strategies to stop the damage.

  • Pathways that Enable Misguided Antibodies to Attack

    We’ve discovered four pathways involved in auto-antibodies—to the body rather than outside invaders—that highlight possible ways to prevent lupus.

  • Molecules that Determine Control of the Immune System

    We’ve described four molecules that act as critical control points for the immune system. These molecules present drug targets for lupus and other autoimmune diseases.

  • Targets for New Treatments

    Promising results are enticing pharmaceutical companies to explore new drugs for lupus for the first time in decades.

  • 20+ New Biomarkers for Diagnosing, Monitoring & Treating Lupus

    Biomarkers are crucial for monitoring, managing, and determining treatment efficacy in lupus.

    Six of the more than 20 identified by LRI investigators are being tested in human tissue and people with lupus.

Research Published

Findings are widely published in the best journals, including Arthritis & Rheumatism, Nature, The Journal of Rheumatology, and Science.

For a sampling of LRI-funded research findings published so far, see News as well as Research Published.